COMPARATIVE ACTIVITIES OF SOME ANTIFUNGAL AGENTS AGAINST DERMATOPHYTE ISOLATES FROM SCHOOL CHILDREN WITH TINEA CAPITIS
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- NGN 5000
ABSTRACT
Tinea capitis is a fungal infection of the scalp and hair caused by dermatophytes. It occurs in all age groups but predominantly found in children. The antifungal activities such as MIC, MFC and rate of kill of fluconazole, terbinafine, lauric acid and sodium propionate alone and in admixture against dermatophyte isolates from school children with tinea capitis in L. E. A. primary school, Mando, Kaduna, Nigeria were assessed. T. mentagrophyte, T. tonsuran, T. rubrum, Trichophyton species M. canis, P. furfur. P. hortei were isolated from the school children. The trichophyton species had the highest order of prevalence (56.67%) followed by P. furfur (20%) while P. hortei was (13.33%) and M.canis was (10%). The Minimum Inhibitory Concentration (MIC) and the Minimum Fungicidal Concentration (MFC) of fluconazole ranges were (0.5- 1.0mg/ml) and (1.00 - 8.00mg/ml) respectively against the test organisms. T. mentagrophyte (isolate number 18) was found to be the most resistant of the organisms that were isolated from the school children. The order of potent activity of the test antifungal agents was fluconazole, terbinafine, lauric acid and sodium propionate. The combination of the test antifungal agents investigated was found to be synergistic. Terbinafine and Sodium propionate combination produced marked synergistic action (FIC=0.57) against the most resistant dermatophyte isolate. Terbinafine (10mg/ml) and Sodium propionate (200mg/ml) after 60mins contact time produced 5.2 and 4.3 log reduction of 1.025 x 108 spores/ml of resistant T. mentagrophyte. The combination of Terbinafine (10mg/ml) and Sodium propionate (200mg/ml) effected 100% kill of 1.02 x108 spores/ml of resistant T. mentagrophyte after 20 minutes contact time. Thus the use of terbinafine/ sodium propionate combination therapy for dermatophyte infection seem promising
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