ABSTRACT
Tinea capitis is a fungal infection of the scalp and hair caused by dermatophytes. It occurs in all age groups but predominantly found in children. The antifungal activities such as MIC, MFC and rate of kill of fluconazole, terbinafine, lauric acid and sodium propionate alone and in admixture against dermatophyte isolates from school children with tinea capitis in L. E. A. primary school, Mando, Kaduna, Nigeria were assessed. T. mentagrophyte, T. tonsuran, T. rubrum, Trichophyton species M. canis, P. furfur. P. hortei were isolated from the school children. The trichophyton species had the highest order of prevalence (56.67%) followed by P. furfur (20%) while P. hortei was (13.33%) and M.canis was (10%). The Minimum Inhibitory Concentration (MIC) and the Minimum Fungicidal Concentration (MFC) of fluconazole ranges were (0.5- 1.0mg/ml) and (1.00 - 8.00mg/ml) respectively against the test organisms. T. mentagrophyte (isolate number 18) was found to be the most resistant of the organisms that were isolated from the school children. The order of potent activity of the test antifungal agents was fluconazole, terbinafine, lauric acid and sodium propionate. The combination of the test antifungal agents investigated was found to be synergistic. Terbinafine and Sodium propionate combination produced marked synergistic action (FIC=0.57) against the most resistant dermatophyte isolate. Terbinafine (10mg/ml) and Sodium propionate (200mg/ml) after 60mins contact time produced 5.2 and 4.3 log reduction of 1.025 x 108 spores/ml of resistant T. mentagrophyte. The combination of Terbinafine (10mg/ml) and Sodium propionate (200mg/ml) effected 100% kill of 1.02 x108 spores/ml of resistant T. mentagrophyte after 20 minutes contact time. Thus the use of terbinafine/ sodium propionate combination therapy for dermatophyte infection seem promising
Insurgency has really caused destruction, povert...
Abstract
Maintaining steady cost projection on construction projects had been until recently an issue of serious concern...
BACKGROUND OF THE STUDY
Skill acquisition has a paramount place in Nigeria’s educational system today. No other ac...
ABSTRACT
A visit to most production company as shows that sourcing now have a great impact on the profitability of a com...
ABSTRACT
The purpose of this research work is to investigate the effect of class size in effective teaching and lear...
Abstract
Croton zambesicus Linn (Euphorbiaceae) is a highly valued medicinal plant in Nigeria and West African sub-region. It is used by...
Abstract
This study focused on the roles of promotional tools as a means of creating customers patronage in banking indu...
Entomologicalsurveyswereconductedtodeterminethebiologicalandphysicochemical parameters influ...
Abstract
It is commonly believed that learning to spell English words demands an understanding of the relationship between sounds and let...
Abstract
The basic aim of the study is to show the impact of production planning and control on productivity in Nigeria...